"The team plans next to study the structures of the Gag proteins in the HIV virus capsule Vegetable Empty Capsule manufacturers after budding, he said.Washington DC: A team of scientists has decoded previously unknown details about the process by which HIV hacks cells to propagate itself. Once inside another unsuspecting cell, the capsule coating falls apart, and the HIV RNA gets to workThe team, including several scholars from the University of Chicago, knew that budding involves an HIV protein complex called Gag protein, but the details of the molecular process were murky. "The hope is that once you have an Achilles heel, you can make a drug to stop Gag accumulation and hopefully arrest the viruss progression.A key part of HIVs success is a nasty little trick to propagate itself inside the body. Simulations allowed them to tweak the model until they arrived at the most likely configurations for the molecular process, which was then validated by experiments in the laboratory of Jennifer Lippincott-Schwartz at the National Institutes of Health and the Howard Hughes Medical Institute Janelia Research Campus.
The findings may offer a new avenue for drugs to combat the virus. The capsule pinches off--a process called "budding"--and floats away to infect more cells."For a while now we have had an idea of what the final assembled structure looks like, but all the details in between remained largely unknown," said corresponding author Gregory Voth."It really demonstrates the power of modern computing for simulating viruses," Voth said.They built a model of missing parts of the Gag protein complex, and tweaked it until they could see how the proteins assemble by taking advantage of cellular infrastructure in preparation for the budding process.The study is published in Proceedings of the National Academy of Sciences. Once HIV has infected a cell, it forces the cell to make a little capsule out of its own membrane, filled with the virus.Since its been difficult to get a good molecular-level snapshot of the protein complex with imaging techniques, Voth and his team built a computer model to simulate Gag in action.
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